Chirag Shah, MD, Cleveland Clinic, Cleveland, OH, discusses the latest advances in radiotherapy for sarcoma. Since the development of limb sparing surgeries for sarcoma, daily radiotherapy is given for 5-6 weeks before and/or after surgery. Dr Shah highlights recent progressive studies that investigate the possibility of shortening radiotherapy duration. A prospective study at MD Anderson Cancer Center investigated the reduction of radiotherapy from 5 weeks to 3 weeks with wound complication rate as its primary endpoint. There was a similar wound complication rate between patients receiving 5 weeks and 3 weeks, with a follow-up study required to investigate cancer recurrence. A further three studies looked at delivering radiotherapy in 5 treatments and found that patients with certain cancers may have improved local control compared to patients receiving 5-6 weeks of radiotherapy. Finally, one study investigated the use of stereotactic radiotherapy for sarcoma patients with lung metastases and found improvements to local control as well as in long term outcomes for patients with controlled systemic disease. This interview took place at the American Society for Radiation Oncology (ASTRO) 2022 Congress in San Antonio, Tx.
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