Chirag Shah, MD, Cleveland Clinic, Cleveland, OH, discusses the results of a study investigating the benefit of radiation therapy following lumpectomy in patients of varying clinical risk levels with ductal carcinoma in situ (DCIS). Patient clinical risk level was determined using a novel biosignature, DCISionRT. This method of categorisation was found to identify clinical risk level more effectively than traditional clinicopathological features. The study found that 37% of the low-risk DCIS patient cohort received no significant benefit of radiation therapy following lumpectomy. Elevated-risk DCIS patients received a significant benefit, with a 15% reduction in recurrence in the breast after radiation therapy following lumpectomy. Finally, residual-risk patients received a significant benefit of radiation therapy following lumpectomy, however risk of recurrence remained elevated by 15%. This interview took place at the American Society for Radiation Oncology (ASTRO) 2022 Congress in San Antonio, Tx.
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