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AACR 2023 | A personalized mRNA vaccine with pembrolizumab in melanoma

Jeffrey Weber, MD, PhD, NYU Langone Medical Center, New York, NY, presents findings from the Phase II Keynote-942 trial (NCT03897881) of mRNA-4157, a personalized mRNA vaccine, with pembrolizumab in patients with resected high-risk melanoma. Patients were randomized to receive the vaccine with pembrolizumab or pembrolizumab alone. Relapse-free survival (RFS) was significantly improved in patients receiving the vaccine without a clinically meaningful increase in side effects. This interview took place at the American Association for Cancer Research (AACR) Annual Meeting 2023 in Orlando, FL.

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