AACR 2023 | Is immunotherapy less effective in patients with PTEN loss in NSCLC?

Francisco Exposito, PhD, Yale University, New Haven, CT, comments on his research on the role of PTEN loss in the efficacy of PD-1 inhibitors in patients with non-small cell lung cancer (NSCLC). Whilst the current models are preclinical, analysis of lung cancer biopsies confirmed previous findings, and mouse models will further elucidate mechanisms of resistance. This interview took place at the American Association for Cancer Research (AACR) Annual Meeting 2023 in Orlando, FL.

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