AACR 2023 | The role of PTEN loss in anti-PD-1 resistance in NSCLC

Francisco Exposito, PhD, Yale University, New Haven, CT, discusses how the loss of PTEN confers resistance to anti-PD-1 therapy in non-small cell lung cancer (NSCLC). The role of PTEN loss in immunotherapy resistance has been studied in other malignancies, and in NSCLC, an increase in tumor infiltration of T regulatory cells was found to contribute to resistance. This interview took place at the American Association for Cancer Research (AACR) Annual Meeting 2023 in Orlando, FL.

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