Ken Kato, MD, PhD, National Cancer Center Hospital, Tokyo, Japan, discusses results from the Asian subgroup of the global, randomized, Phase III RATIONALE-306 trial (NCT03783442), which compared tislelizumab plus chemotherapy vs chemotherapy alone in the first-line setting for patients with advanced/metastatic esophageal squamous cell carcinoma. There were 4 different chemotherapy regimens used in the trial, which sets this trial apart from other trials investigating the same area. A notable aspect of the results was the hazard ratios of the PD-L1-negative and PD-L1-positive populations. Similar clinical trials have previously showed worse hazard ratios in the PD-L1-negative population, compared to PD-L1-positive, however in this trial the hazard ratio in the PD-L1-negative and PD-L1-positive populations were similar. This interview took place at the European Society for Medical Oncology (ESMO) Asia congress 2022 in Singapore.
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