Prasad Adusumilli, MD, Memorial Sloan Kettering Cancer Center, New York, NY, talks on the main challenges associated with poor efficacy of CAR-T cells in solid tumors, including limited infiltration by the effector T-cells, as well as the immunosuppressive microenvironment and heterogenous antigen expression. Following efficient infiltration in solid tumors with CAR-T cells, immune checkpoint blockade may be a viable approach to promote the functional persistence of CAR-T cells. This interview took place at the Immunotherapy of Cancer (ITOC) Conference 2022 in Munich, Germany.
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