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ITOC 2022 | Armoring anti-HER2 CAR-T cells with CCR8 and a DNR to enable efficacy in solid tumor models

Thaddäus Strzalkowski, Ludwig-Maximilians-Universität München, Munich, Germany, talks on armoring anti-HER2 CAR-T cells with C-C-motive receptor 8 (CCR8) and a dominant negative TGF-b receptor (DNR) to enable CAR-T cell efficacy in solid tumor models. Through investigation via primary murine and human T-cells, as well as murine models, it was demonstrated that the expression of CCR8 can redirect CAR T cells to the tumor and a DNR can prevent immunosuppression of CAR T cells in the tumor microenvironment. This interview took place at the Immunotherapy of Cancer (ITOC) Conference 2022 in Munich, Germany.

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