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GU Cancers 2026 | Long-term mental health burden after prostate cancer diagnosis

Gabriela Ilie, PhD, Dalhousie University, Halifax, Canada, discusses the increased risk of depression and anxiety in men with a history of prostate cancer diagnosis, highlighting that this risk remains elevated even 15-18 years after diagnosis and is a systemic issue observed globally. Quality of life of these patients is affected by various factors beyond functional issues, including treatment regret, worry about family and friends, and uncertainty about the future, which can contribute to a silent epidemic of anxiety and depression. This interview took place at the 2026 ASCO GU Cancers Symposium in San Francisco, CA.

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Transcript

Compared to the normal population, men who have had a history of prostate cancer diagnosis have doubled the risk of depression, anxiety, or both. And what’s really worrisome is that even 15, 16, 18 years after the diagnosis, we find that the prevalence for those conditions is much higher among men with a history of prostate cancer diagnosis compared to men in the general population...

Compared to the normal population, men who have had a history of prostate cancer diagnosis have doubled the risk of depression, anxiety, or both. And what’s really worrisome is that even 15, 16, 18 years after the diagnosis, we find that the prevalence for those conditions is much higher among men with a history of prostate cancer diagnosis compared to men in the general population. And this is a systemic issue. So it’s not just in Canada. It’s not just in the U.S. We find it in Australia. We find it in Europe. So it’s all over the place. So this is very serious because this means that there is another factor and an exponential factor that affects the quality of life of this particular population. It’s not just functional. And a lot of the time we think, oh, you know, urinary problems, sexual problems. No wonder why they’re suffering. But in fact, there are others. Alicia Morgan from Boston calls them the X factor. There are things like, you know, treatment regret, worrying about family and friends, not knowing what to expect, wait times between appointments, between scans and so on, that all together compile a lot of anxiety and issues that remain buried, you know, because men present well. So you might think nothing is the matter when in fact there is a lot the matter so we’re looking at a silent epidemic that is preventable it’s not just function you know we’re very good at monitoring testosterone levels but we’re not very good at monitoring people’s anxiety levels

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