Jean-Philippe Girard, PhD, CNRS-Université de Toulouse III, Toulouse, France, discusses the mediation of lymphocyte entry into tumors via tumor-associated high endothelial venules (HEVs). Using murine mouse models, tumor-associated HEVs (TA-HEVs) were demonstrated to be significant sites of lymphocyte entry into tumors at baseline and upon treatment with anti-PD-1/anti-CTLA-4 immune checkpoint blockade. Analysis of tumor biopsies from patients with metastatic melanoma revealed TA-HEVs are predictive of better response to the combination of anti-PD-1 and anti-CTLA-4 treatment. This interview took place at the Molecular Analysis for Precision oncology (MAP) Congress 2022 in Amsterdam, Netherlands.
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