Educational content on VJOncology is intended for healthcare professionals only. By visiting this website and accessing this information you confirm that you are a healthcare professional.

Share this video  

ESMO MAP 2022 | HEVs and lymphocyte recruitment in tumors in response to immune checkpoint blockade

Jean-Philippe Girard, PhD, CNRS-Université de Toulouse III, Toulouse, France, discusses the mediation of lymphocyte entry into tumors via tumor-associated high endothelial venules (HEVs). Using murine mouse models, tumor-associated HEVs (TA-HEVs) were demonstrated to be significant sites of lymphocyte entry into tumors at baseline and upon treatment with anti-PD-1/anti-CTLA-4 immune checkpoint blockade. Analysis of tumor biopsies from patients with metastatic melanoma revealed TA-HEVs are predictive of better response to the combination of anti-PD-1 and anti-CTLA-4 treatment. This interview took place at the Molecular Analysis for Precision oncology (MAP) Congress 2022 in Amsterdam, Netherlands.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.