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ASCO 2026 | Real-world safety of adoptive cellular therapy with lifileucel in patients with advanced melanoma

Alexandra Haugh, MD, MPH, of Massachusetts General Hospital Cancer Center, discusses real-world safety outcomes with lifileucel adoptive cellular therapy in patients with advanced melanoma. Dr Haugh highlights the high rates of prolonged cytopenias and post-treatment infections observed following lymphodepleting chemotherapy and tumor-infiltrating lymphocyte (TIL) therapy, while noting relatively low rates of organ dysfunction and immune-related toxicities. This interview took place during the 2026 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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