Nicolas Girard, MD, PhD, Institut Curie, Paris, France, discusses the primary results of the Phase III PAPILLON (NCT04538664) trial of amivantamab plus chemotherapy (ami-chemo) versus chemotherapy as first-line treatment in EGFR Exon 20 insertion-mutated advanced non-small cell lung cancer (NSCLC). In the ami-chemo group, patients experienced a significantly longer progression-free survival (PFS) of 11.4 months compared to 6.7 months in the chemotherapy group. Ami-chemo also had a higher objective response rate (73% vs. 47%). The study demonstrated a favorable trend in overall survival for ami-chemo. The safety profile was in line with each individual agent, with 7% of patients discontinuing ami due to treatment-related adverse events. PAPILLON establishes ami-chemo as the new standard of care for first-line treatment in EGFR Ex20ins advanced NSCLC. This interview took place at the European Society for Medical Oncology (ESMO) 2023 Congress in Madrid, Spain.
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