Hope Rugo, MD, FASCO, UCSF Comprehensive Cancer Center, San Diego, CA, discusses the BYLieve study (NCT03056755), which will add to the data accrued on alpelisib in the SOLAR-1 study where few patients had prior CDK4/6 inhibitor treatment. This ongoing phase 2, multicenter, open-label, noncomparative study is assessing alpelisib plus endocrine therapy (fulvestrant or letrozole) in patients with PIK3CA-mutated HR+/HER2- advanced breast cancer who progressed on or after prior treatments. This interview took place at the European Society for Medical Oncology (ESMO) 2019 congress in Barcelona, Spain.