So B7H3 is an immunomodulatory protein that’s expressed on the surface of many types of cancer cells and with castration-resistant prostate cancer in particular, B7H3 tends to be quite ubiquitous with an expression level of over 90% in most cells and so this made sense as a target for this particular agent and it’s also been an agent that’s been effective in many other cancer types, so particularly small cell lung cancer, hepatocellular carcinoma, and several other solid tumors...
So B7H3 is an immunomodulatory protein that’s expressed on the surface of many types of cancer cells and with castration-resistant prostate cancer in particular, B7H3 tends to be quite ubiquitous with an expression level of over 90% in most cells and so this made sense as a target for this particular agent and it’s also been an agent that’s been effective in many other cancer types, so particularly small cell lung cancer, hepatocellular carcinoma, and several other solid tumors.
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