Educational content on VJOncology is intended for healthcare professionals only. By visiting this website and accessing this information you confirm that you are a healthcare professional.

Share this video  

ESMO 2025 | The benefits of biomarker-driven drug development in sarcomas

Qiyuan Bao, MD, Shanghai Ruijin Hospital, Shanghai, China, comments on the limitations of anti-angiogenic therapy in sarcoma treatment, highlighting the lack of identified biomarkers and the resulting trial-and-error approach that can lead to unnecessary toxicities. Dr Bao emphasizes the need to improve this situation and notes that BIOVAS trial (NCT04072042) aims to demonstrate the superiority of a biomarker-driven approach over an all-comer approach. This interview took place at the European Society for Medical Oncology (ESMO) 2025 Congress in Berlin, Germany.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

Transcript

As you can tell from the name, the target therapy, by definition, as everybody understands it, should be targeting the right tumor with the right target with the right patients, and it is very sarcastic that in our field, although the anti-angiogenic therapy as a target therapy has been given to our patients for more than one decade, there are no single biomarkers identified...

As you can tell from the name, the target therapy, by definition, as everybody understands it, should be targeting the right tumor with the right target with the right patients, and it is very sarcastic that in our field, although the anti-angiogenic therapy as a target therapy has been given to our patients for more than one decade, there are no single biomarkers identified. And to date, most patients with sarcoma are given anti-angiogenic therapy in a trial-and-error approach, which means that a lot of these patients are given additional toxicities without giving them additional benefits of this drug. So we really want to improve this situation. So in this study, we really want to demonstrate the superiority of using a biomarker-driven approach rather than an all-comer approach in this study, and that’s the main advantage of our study.

This transcript is AI-generated. While we strive for accuracy, please verify this copy with the video.

Read more...