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ASCO 2026 | Phase I trial of neoadjuvant rintatolimod and celecoxib in resectable mCRC
Sarbajit Mukherjee, MD, MS, Miami Cancer Institute, Miami, FL, comments on results from a Phase I study (NCT01545141) of a neoadjuvant chemokine-modulating regimen of interferon alpha, rintatolimod, and celecoxib in resectable metastatic colorectal cancer. The regimen was safe and feasible, with no dose-limiting toxicities. All patients underwent complete resection. Tissue analysis demonstrated favorable immune modulation within the tumor microenvironment, including increased effector T-cell ratios. These findings support further investigation of this approach combined with immunotherapy or chemotherapy to improve oncologic outcomes. This interview took place during the 2026 ASCO Meeting in Chicago, IL.
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