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ASCO 2026 | Real-world brain metastasis outcomes with T-DXd vs tucatinib-based therapy in second-line HER2+ mBC

Zunairah Shah • 30 May 2026
ASCO 2026
Breast Cancer Antibodies Capecitabine Trastuzumab deruxtecan Tucatinib

Zunairah Shah, MD, Roswell Park Comprehensive Cancer Center, Buffalo, NY, discusses a real-world analysis comparing trastuzumab deruxtecan (T-DXd) with tucatinib-based therapy in second-line HER2-positive metastatic breast cancer (mBC). Dr Shah highlights the lower incidence of brain metastases and improved brain metastasis-free survival observed with T-DXd, supporting its potential role in reducing CNS progression in clinical practice. This interview took place during the 2026 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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