The National Institute for Health and Care Excellence (NICE) in the UK has rejected osimetinib for the treatment of EGFR+ non-small cell lung cancer (NSCLC). Here, Riyaz Shah, FRCP, PhD, The Royal Marsden Hospital, London, UK, discusses this decision and what in means for the treatment of this group in the UK. This interview took place at the 18th British Thoracic Oncology Group (BTOG) 2020 congress held in Dublin, UK.