Annelie Johansson, PhD, Karolinska Institutet, Stockholm, Sweden, discusses differential long-term benefit from adjuvant tamoxifen therapy in estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative premenopausal and postmenopausal breast cancer patients. Secondary analysis was carried out of 1242 ER-positive/HER2-negative patients from the Stockholm tamoxifen (STO)-trials who had been randomized to receive tamoxifen or no endocrine therapy with complete 20-years follow-up. When evaluating clinically used tumor characteristics, postmenopausal patients with a low-risk were observed to obtain a long-term benefit from tamoxifen, whereas fewer clinically used tumor characteristics corresponding to good prognosis were associated with tamoxifen benefit in premenopausal patients. Time-varying analysis in premenopausal patients indicated that tamoxifen therapy benefit diminished over time, whereas postmenopausal patients were shown to have longer-term benefit. This interview took place at the San Antonio Breast Cancer Symposium (SABCS) 2022 in San Antonio, TX.
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