Cesare Piazza, MD, University of Brescia, Brescia, Italy, discusses the future of artificial intelligence (AI) in cancer care, especially in the field of videomics. Machine learning has great potential in this area, with research currently working to improve AI interpretation of video endoscopies. Prof. Piazza highlights the large advances in AI in recent years, and discusses possibilities for future uses, for example as a replacement for biopsy in certain situations. This interview took place at the joint International Congress on Innovative Approaches in Head and Neck Oncology and the European Congress on Head and Neck Oncology (ICHNO-ECHNO) 2022 hybrid meeting in Brussels, Belgium.