Cesare Piazza, MD, University of Brescia, Brescia, Italy, discusses some of the big topics at the ICHNO-ECHNO 2022 congress, including artificial intelligence, radiotherapy, and immunotherapy in head and neck cancer. This interview took place at the joint International Congress on Innovative Approaches in Head and Neck Oncology and the European Congress on Head and Neck Oncology (ICHNO-ECHNO) 2022 hybrid meeting in Brussels, Belgium.