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ASCO 2026 | BLUESTAR: puxitatug samrotecan safety & efficacy in endometrial or ovarian cancer

Linda Mileshkin, MBBS, MD, Peter MacCallum Cancer Centre, Melbourne, Australia, discusses updated safety and efficacy data from the Phase I/IIa BLUESTAR trial (NCT05123482) of puxitatug samrotecan, a B7-H4-directed antibody-drug conjugate (ADC), in patients with relapsed/metastatic endometrial or ovarian cancer. The agent demonstrated a favorable safety profile and robust antitumor activity across both tumor types. This interview took place during the 2026 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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