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ASCO 2023 | EV-103: EV with pembrolizumab in cisplatin-ineligible urothelial carcinoma

Shilpa Gupta, MD, Cleveland Clinic, Cleveland, OH, describes the rationale and trial design of the EV-103 trial (NCT03288545), which assessed enfortumab vedotin (EV), an antibody-drug conjugate (ACD), and pembrolizumab in patients with first-line cisplatin-ineligible locally advanced or metastatic urothelial carcinoma. The combination of EV and pembrolizumab had encouraging antitumor activity and a manageable safety profile in cohort A, which had a dose escalation component, and cohort K. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.

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