SITC 2022 | ONM-405: pH activated nanoparticle for activating NK- and T-cells in solid tumors

Jinming Gao, PhD, UT Southwestern Medical Center, Dallas, TX, provides an overview of ONM-405, a nanoparticle formulated cytokine, IL-2Fc, designed to increase the therapeutic window of IL-2 via a pH activatable micelle formulation. ONM-405 encapsulates the IL-2 cytokine during circulation. The IL-2 cytokine is then released into solid cancers upon reaching the tumors acidic microenvironment to activate NK cells and T-cells. This interview took place at the 37th Annual Meeting of the Society for Immunotherapy in Cancer (SITC 2022) in Boston, MA.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.