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ASCO 2026 | EIK1003-001: Phase I/II trial of EIK1003 in PROC and HER- breast cancer

Martin Hojgaard, MD, Rigshospitalet, Copenhagen, Denmark, presents initial clinical data from EIK1003-001 (NCT06253130), a Phase I/II study evaluating EIK1003, a selective PARP1 inhibitor, with paclitaxel in patients with platinum-resistant recurrent ovarian cancer (PROC) and HER2-negative breast cancer. A manageable safety profile was reported in a heavily pre-treated population, with hematologic toxicities comparable to historical paclitaxel use, alongside preliminary antitumor activity across both monotherapy and combination cohorts. This interview took place during the 2026 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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Transcript

So the EIK1003-001, this is the phase one part we’re going to present. The main results, the main takeaway is that the selective PARP1 inhibitors are safe and efficacious both in monotherapy and in particular in combination therapy with weekly paclitaxel. So this would be for the combination therapy, which I think we should focus the most on, where we combined the selective PARP1 inhibitors with weekly paclitaxel, showed encouraging safety results and also an objective response rate of 24% in heavily pretreated cancer patients with breast and ovarian cancer...

So the EIK1003-001, this is the phase one part we’re going to present. The main results, the main takeaway is that the selective PARP1 inhibitors are safe and efficacious both in monotherapy and in particular in combination therapy with weekly paclitaxel. So this would be for the combination therapy, which I think we should focus the most on, where we combined the selective PARP1 inhibitors with weekly paclitaxel, showed encouraging safety results and also an objective response rate of 24% in heavily pretreated cancer patients with breast and ovarian cancer.

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