Patrick Neven, MD, Universitair Ziekenhuis Leuven, Leuven, Belgium, provides an overview of updated results of the Phase III monarchE (NCT03155997) trial investigating abemaciclib plus endocrine therapy for ER-positive, HER2-negative (ER+/HER2-), node-positive, high-risk early breast cancer. Previous results from the monarchE trial demonstrated a significant and clinically meaningful improvement in invasive disease-free survival (IDFS) and distant relapse-free survival (DRFS). 4-year follow-up results were presented at the San Antonio Breast Cancer Symposium (SABCS) 2022. At a median follow-up of 42 months, median IDFS was not reached in either group and the IDFS benefit previously reported was sustained. At 4 years, IDFS rates had improved from 79.4% to 85.8% (absolute difference 6.4%), and DRFS rates from 82.5% to 88.4% (absolute difference 5.9%). Overall, the results show an increasing benefit with abemaciclib plus endocrine therapy over endocrine therapy alone in the adjuvant setting for ER+/HER2- high-risk early breast cancer. This interview took place at the San Antonio Breast Cancer Symposium (SABCS) 2022 in San Antonio, TX.
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