WCLC 2023 | KontRASt-01: JDQ443 and TNO155 in the treatment of NSCLC

Marcelo Negrao, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses the results of the Phase Ib KontRASt-01 trial (NCT04699188) in which patients with non-small cell lung cancer (NSCLC) with advanced solid tumors were treated with JDQ443 (a KRAS-G12C inhibitor) and TNO155 (a SHP2 inhibitor). Responses were observed in both KRAS-G12C treatment-naïve and pre-treated patients, where encouraging confirmed objective response rates (ORR) were observed both groups. Dr Negrao also discusses the safety profile of the treatment, where the investigational regimen was tolerable in patients. This interview took place at the 2023 World Conference on Lung Cancer (WCLC) in Singapore, Singapore.

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