Paolo Bossi, MD, University of Brescia, Brescia, Italy, reflects on ongoing treatment approaches currently under investigation in patients with cutaneous squamous cell carcinoma, including the role of combined systemic immunotherapy and intra-tumoral injection of a modified herpes-simplex virus with the intention to improve response to immune checkpoint blockade. This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.