Sanjay Popat, BSc, MBBS, FRCP, PhD, The Royal Marsden NHS Foundation Trust, London, UK, discusses the results of the Checkmate 171 (NCT02409368) and PePS2 (NCT02733159) studies which have highlighted a significant benefit of checkpoint blockade therapy for advanced non-small cell lung cancer (NSCLC) patients. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).