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ASCO 2024 | Pooled analysis of management of nausea and vomiting in patients treated with T-DXd

Yeon Hee Park, MD, Samsung Medical Center, Seoul, South Korea, comments on the incidence and management of nausea and vomiting in patients treated with trastuzumab deruxtecan (T-DXd). A pooled analysis of several clinical trials (DESTINY-Breast01, -Breast02, -Breast03, -Breast04, -Lung01, -Lung02; NCT03248492, NCT03523585, NCT03529110, NCT03734029, NCT03505710, NCT04644237, NCT02564900) in various tumor types, including metastatic low breast cancer, HER2+ gastric cancer, and HER2-mutant non-small cell lung cancer (NSCLC), revealed that a majority of patients experienced nausea and vomiting. Effective prophylaxis and management strategies are crucial for maintaining treatment adherence and duration. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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