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ESMO 2026 | Current treatment landscape for anti-PD-1 resistant advanced melanoma

Barbara Ma, MD, MS, Weill Cornell Medicine, New York, NY, discusses the current treatment landscape for patients with advanced melanoma who progress on anti-PD-1 therapy, highlighting the limited options of immunotherapy, targeted therapy, or chemotherapy. Dr Ma comments on the approval of lifileucel for patients who have progressed on anti-PD-1 therapy and the potential survival benefit of lifileucel based on an indirect comparison adjusting for baseline patient characteristics. This interview took place at the European Society for Medical Oncology (ESMO) 2026 Congress in Madrid, Spain.

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