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Morgan Roupret, MD, PhD, from the Pitié-Salpétrière Hospital, Paris, France, discusses preventing cystectomy in patients with advanced and complicated bladder cancer at the European Association of Urology (EAU) conference 2017 in London, UK. Currently, treatment for patients with advanced bladder cancer or urothelial inversion is a cystectomy. This has a significant impact on the patient’s quality of life. This can be avoided by removing the tumour, without performing a cystectomy, and treating circulating cells with systemic treatment, which will be available in the near future.