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Davide Smussi, MD, ASST Spedali Civili di Brescia, Brescia, Italy, comments on the main reason for treatment deviation in a patients with head and neck squamous cell carcinoma (HNSCC), which was the multidisciplinary team (MDT) judgment due to high disease burden and nodal burden, leading to the need for induction chemotherapy in some cases. Deviating from clinical guidelines can have a detrimental impact on patient survival, although the absence of baseline information on comorbidities is a potential confounding factor. This interview took place at the European Society for Medical Oncology (ESMO) 2026 Congress in Madrid, Spain.
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