ASCO GI 2024 | Emerging immunotherapy biomarkers for predicting systemic therapy in HCC

Mark Yarchoan, MD, Johns Hopkins University, Baltimore, MD, provides an overview of emerging immunotherapy biomarkers for predicting systemic therapy in hepatocellular carcinoma (HCC). He highlights the challenge of lacking an effective biomarker to choose between various regimens for first-line HCC treatment. Dr Yarchoan mentions that multiple biomarkers, such as tumor mutational burden and PD-L1 expression, have been investigated, but none have proven effective in this context. He discusses the controversy surrounding the potential relationship between etiology and immunotherapy response, emphasizing that, based on the available data, etiology should not be a determining factor in selecting first-line systemic regimens for HCC. This interview took place at the 2024 ASCO Gastrointestinal (GI) Cancers Symposium in San Francisco, CA.

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