Philipp Karschnia, MD, Ludwig-Maximilians-University of Munich, Munich, Germany, reflects on the role of neurosurgery in the management of patients with cancer and central nervous system (CNS) metastases. With the onset of novel immunotherapies and targeted therapies, neurosurgery has become a viable treatment modality for more patients with cancer. This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.