Philipp Karschnia, MD, Ludwig-Maximilians-University of Munich, Munich, Germany, discusses exciting updates in the management of brain tumors and central nervous system metastases presenting during the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting, including approaches comparing photon versus proton irradiation in patients with leptomeningeal disease. This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.