Cigarette smoking is a known risk factor for bladder cancer and smokers have been reported to have a greater number of mutations compared to non-smokers. In this interview, Nishita Tripathi, MD, University of Utah, Salt Lake City, UT, discusses the results of a retrospective study assessing the frequency of targetable genomic alterations in smokers (current or past) vs never smokers patients (pts) with locally advanced or metastatic urothelial carcinoma (mUC). This interview took place at the American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium 2022 in San Francisco, CA.