Erika Hamilton, MD, Sarah Cannon Research Institute, Nashville, TN, discusses CAPItello-292 (NCT04862663), a Phase Ib/III trial of capivasertib, palbociclib and fulvestrant versus palbociclib and fulvestrant for hormone receptor-positive (HR+) patients with endocrine-resistant advanced breast cancer. Dr Hamilton mentions promising results for AKT inhibitors in previous studies and highlights how this triplet combination could provide great insight. This interview took place at the European Society for Medical Oncology (ESMO) 2021 congress.