Small cell lung cancer (SCLC) transformation is a mechanism for acquired resistance to EGFR tyrosine kinase inhibitor therapy in non-small cell lung cancer (NSCLC). Triparna Sen, PhD, MS, BS, Memorial Sloan Kettering Cancer Center, New York, NY, outlines neuroendocrine transformation in lung cancer and it’s role in resistance. This interview took place during the virtual European Lung Cancer Congress 2022.