Hendrik Van Poppel, MD, PhD, from KU Leuven, Leuven, Belgium, discusses localized approaches in the treatment of prostate cancer at the European Association of Urology (EAU) conference in 2017 in London, UK. He explains that the current landscape is primarily hypofractionated radiation therapy, and prostatectomy, which is more recently being carried out by robotic surgery. Photodynamic therapy (PDT) is a novel treatment that has shown to be effective. PDT is promising because it does not carry the same risks as more conventional treatments, and there is potential for it to be used in patients with low risk prostate cancer under active surveillance who ask for localized treatment.