Alexander Spira, MD, PhD, FACP, Virginia Cancer Specialists, Fairfax, VA, presents data from the expansion cohort of the Phase I/II study (NCT02716116) evaluating mobocertinib in patients with non-small cell lung cancer (NSCLC), which included patients pre-treated with tyrosine kinase inhibitors (TKIs). Although the cohort’s sample size was relatively small, it suggested that mobocertinib is more efficacious than other TKIs. This interview took place at the World Conference on Lung Cancer (WCLC) 2021.