Neal Navani, MA, MRCP, MSc, PhD, Care Quality Improvement Department, Royal College of Physicians, London, UK, provides an overview of challenges clinicians face in gene testing for actionable mutations in the UK. Whilst genetic testing is offered to all patients with severe lung cancer regardless of age or smoking status, the quality of tissue remains inconsistent and the median time to process the tissue can be up to 19 days. Expediting the processing time is necessary to provide the best treatment options for patients. This interview took place at the 20th Annual British Thoracic Oncology Group (BTOG) Conference 2022.