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ASCO 2025 | Key therapeutic markers in gastroesophageal cancers: HER2, PDL1, MSI & more

Ronan Kelly, MD, Charles A. Sammons Cancer Center at Baylor University Medical Center, Dallas, TX comments on the therapeutic landscape surrounding gastroesophageal cancers. He highlights four therapeutic targets that are currently of mainstream focus: HER2, PDL1, microsatellite instability (MSI), and CLDN18.2, and notes evidence targeting CDK4/6 is primarily in a investigator-initiated Phase I/II trial (NCT04921904). This interview took place at the 2025 American Society of Clinical Oncology (ASCO) meeting in Chicago, IL.

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