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ASCO 2025 | Addressing the escalating impact of alcohol on cancer outcomes

Chinmay Jani, MBBS, Sylvester Comprehensive Cancer Center, Doral, FL, comments on the potential relationship between alcohol consumption and cancer mortality, highlighting the need for stratified analysis across different age groups and geographic regions. Dr Jani suggests exploring dose-response relationships and mechanisms underlying the association, with a focus on specific cancers and the impact of alcohol on gut microbiomes and immune checkpoint inhibitors. This interview took place during the 2025 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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Transcript

At our University of Miami we are trying to understand more of the dietary correlation of different microbiome along with cancer mortality as well with different treatment and outcomes based on that. But based on particularly alcohol we want to look into more stratified analysis whether it’s just based on in United States or across the globe as well and try to identify more at a granular level how the association is impacting...

At our University of Miami we are trying to understand more of the dietary correlation of different microbiome along with cancer mortality as well with different treatment and outcomes based on that. But based on particularly alcohol we want to look into more stratified analysis whether it’s just based on in United States or across the globe as well and try to identify more at a granular level how the association is impacting. Our next steps would be that the hypothesis generations are basically, is there a dose-response relationship? If you’re drinking early in your younger age group, when you’re young, is it leading to more cancer death when you are elder? Above 55, for example. Other possibilities are we need to look into what’s the mechanism leading to that as well, about each particular cancer. So those are lots of different hypotheses that we really want to look into. into. From our research group standpoint, we are going to look into more granular data in the US, as well as across the country for alcohol and cancer, and then also looking into gut microbiome and dietary impacts of alcohol and other risk factors in different immune checkpoint inhibitors too.

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