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ASCO 2025 | Improving early clinical trial enrolment in pediatric oncology

Lesleigh Abbott, MD, The Children’s Hospital of Eastern Ontario, Ottawa, Canada, gives an overview of barriers to early-phase clinical trial enrolment for pediatric patients with cancer. Limitations include the lack of availability of trials, exacerbated by Canada’s vast geography and limited trial locations. To address this, increasing the number of trials at multiple centers, providing support to patients and families to access trials at other centers, and potentially creating satellite models from main hubs to increase accessibility are suggested. This interview took place during the 2025 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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Transcript

So we focused on early-phase clinical trials. And one of the main barriers that we saw to that was a lack of availability of trials. On top of Canada being a very large country with many hours in between centers. And our early-phase clinical trials are really focused at certain centers. So there was sometimes a lack of access for other patients or it meant traveling or it meant a cost to the family...

So we focused on early-phase clinical trials. And one of the main barriers that we saw to that was a lack of availability of trials. On top of Canada being a very large country with many hours in between centers. And our early-phase clinical trials are really focused at certain centers. So there was sometimes a lack of access for other patients or it meant traveling or it meant a cost to the family. So these are important things to keep in mind and looking for ways to overcome that. So is that more trials being at more centers? Is that offering supports to patients and families so they can access trials that are at other centers? And is it about the centers getting together and perhaps creating more satellite models from the main hubs?

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