ASCO 2025 | How can we overcome immune resistance in patients with melanoma?
Anna Maria Di Giacomo, MD, University Hospital of Siena, Siena, Italy, comments on streategies to overcome resistance to anti-PD-1 and anti-CTLA-4 treatments in melanoma. Combining tumor infiltrating lymphocytes (TILs) with immune checkpoint therapy may be a promising strategy in melanoma, and other tumors such as lung cancer, endometrial cancer, and gynecological cancer. This approach has shown potential in previous studies and is expected to be investigated further in upcoming trials. This interview took place during the 2025 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
Transcript
Several trials have to overcome resistance to anti-PD-1 and a potential strategy in the near future, I think, and very interesting data was also presented this year, on the cellular therapy. Because in the previous studies also in the next few years, the authors demonstrated that (tumor) infiltrating lymphocytes could be combined with immune checkpoint in patients who have previously received an anti-PD-1 or anti-CTLA-4, so immunotherapy more in general...
Several trials have to overcome resistance to anti-PD-1 and a potential strategy in the near future, I think, and very interesting data was also presented this year, on the cellular therapy. Because in the previous studies also in the next few years, the authors demonstrated that (tumor) infiltrating lymphocytes could be combined with immune checkpoint in patients who have previously received an anti-PD-1 or anti-CTLA-4, so immunotherapy more in general. Not only in melanoma really, because also in lung cancer, endometrial cancer, gynecological cancer, in the near future, several trials are to investigate the potential of T-cell infiltrating lymphocytes with immune checkpoint to overcome resistance. Thank you.
This transcript is AI-generated. While we strive for accuracy, please verify this copy with the video.
Read more...
