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ESMO 2025 | How will prophylactic nodal irradiation have a role in head and neck cancer?

Takeshi Kodaira, MD, PhD, Aichi Cancer Center, Nagoya, Japan, comments on the implications of the findings from the JCOG1912 (NEW BRIDGE) trial (jRCTs031210100) on prophylactic nodal irradiation in head and neck cancer, noting that the current standard treatment of approximately 50 Gy of prophylactic radiation demonstrates sufficient efficacy. Less invasive treatment approaches, therefore, need to be evaluated in well-designed clinical trials with appropriate patient selection based on recurrence risk. This interview took place at the European Society for Medical Oncology (ESMO) 2025 Congress in Berlin, Germany.

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Transcript

As you know, several less invasive treatment strategies have been explored to reduce toxicity. However, no clear advantage in terms of adverse events without compromising efficacy has been reported to date. Our study supports the current standard treatment, which included approximately 50 Gy of prophylactic radiation, such as SIB56 in definitive chemoradiation IMRT, demonstrating sufficient efficacy...

As you know, several less invasive treatment strategies have been explored to reduce toxicity. However, no clear advantage in terms of adverse events without compromising efficacy has been reported to date. Our study supports the current standard treatment, which included approximately 50 Gy of prophylactic radiation, such as SIB56 in definitive chemoradiation IMRT, demonstrating sufficient efficacy. Less invasive treatment approaches should be evaluated in well-designed clinical trials with appropriate patient selection based on recurrence risk.

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