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ASCO GI 2026 | BRCA testing in metastatic pancreatic cancer: guidelines and treatment implications

Teresa Macarulla, MD, Vall d’Hebron University Hospital, Barcelona, Spain, discusses the current understanding of DNA damage repair deficiencies in pancreatic cancer, and how genomic profiling is changing the approach to identifying and treating this molecularly defined subset of patients, especially as a result of the findings of the POLO trial (NCT02184195). This interview took place at the 2026 American Society of Clinical Oncology Gastrointestinal Cancers Symposium in San Francisco, CA.

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