SABCS 2025 | Dendritic cell therapy: immune cell collection and production process
Peter Forsyth, MD, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, provides an overview of the process of collecting and producing immune cells for dendritic cell therapy, noting that it is a relatively straightforward process that can be done at a major cancer center with a cell therapy facility. The cells are collected from a patient’s arm or port over several hours, then isolated and cultured with chemicals to produce more dendritic cells, although some patients may not have enough immune cells due to chemotherapy interference. This interview took place at the San Antonio Breast Cancer Symposium (SABCS) 2025 Meeting in San Antonio, TX.
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Transcript
Yeah, I don’t think that’s a significant problem. I mean, if it’s a home run, for sure, it’s not that challenging. You just need a place like Moffitt or some other major cancer center that has a cell therapy facility that can produce the cells. But it’s not tricky. It’s pretty straightforward. And then I, I didn’t tell you that, which I completely glossed over, but we collect the cells from, you know, the vein of a patient’s arm, for example, or in a port...
Yeah, I don’t think that’s a significant problem. I mean, if it’s a home run, for sure, it’s not that challenging. You just need a place like Moffitt or some other major cancer center that has a cell therapy facility that can produce the cells. But it’s not tricky. It’s pretty straightforward. And then I, I didn’t tell you that, which I completely glossed over, but we collect the cells from, you know, the vein of a patient’s arm, for example, or in a port. And then we just collect those over about eight hours, take out the relevant immune cells and then stick them in a dish with cocktails and chemicals. And so they make more dendritic cells. So it’s not that difficult. The only challenge is maybe 20% or 30% of the time these poor women don’t have enough immune cells because they’ve got a bunch of chemo that’s interfered with the bone marrow. So maybe 30% of the time they just don’t have enough active cells that will grow, which is super frustrating.
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