SABCS 2022 | A study of talazoparib in somatic BRCA1/2 mutant MBC identified by cfDNA or tumor tissue genotyping

Neelima Vidula, MD, Massachusetts General Hospital, Boston, MA, talks on an ongoing Phase II study (NCT03990896) of talazoparib, a PARP inhibitor, in somatic BRCA1/2 mutant metastatic breast cancer identified by cell-free DNA or tumor tissue genotyping. PAPR inhibitors are currently approved for germline BRCA1/2 HER2-positive metastatic breast cancer. However, germline BRCA mutant breast cancer only accounts for 5-10% of breast cancer. The Phase II study is examining whether the population that benefits from PARP inhibitors can be expanded upon. It had previously been demonstrated that somatic BRCA1/2 mutations can be identified by both cell-free DNA and tumor tissue genotyping in a subset of patients with metastatic breast cancer who are not germline BRCA1/2 carriers. Patients will be treated with talazoparib, a PARP inhibitor, until disease progression. At baseline and every 3 months, patients undergo CT chest, abdomen, and pelvis, and a bone scan for disease assessment. Primary aim is progression-free survival (PFS) assessed by RECIST 1.1. Secondary aims include objective response rate and toxicity assessed by NCI CTCAE v 5.0. This interview took place at the San Antonio Breast Cancer Symposium (SABCS) 2022 in San Antonio, TX.

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